CLOCKSHIFT

Breast cancer risk and epigenetic effects of the rotating night shift work and lifestyle.

WP2

Epigenetic changes in core circadian genes, melatonin receptor genes, and female hormone receptor genes and breast cancer risk in Norwegian nurses

Leader: Ph.D. Shanbeh Zienolddiny

The main objective of this work package is to investigate epigenetic changes (levels of 5-methyl cytosine) in core circadian genes, melatonin receptor genes, and female hormone receptor genes in relation to night work and risk of breast cancer.
A secondary objective is to study the functional effects of some polymorphisms of these genes that might be involves in breast cancer. Molecular and data analyses will be performed at the National Institute of Occupational Health in Oslo, Norvway, using DNA samples collected from 563 nurses with breast cancer and matched 619 healthy controls (for more information, see "Study population"). Three exposure groups will be compared: only-day workers, short-term night shift workers and long-term night shift workers.